Cell / animal study· 2013
Evaluation of metabolically stabilized angiotensin IV analogs as procognitive/antidementia agents.
The Journal of pharmacology and experimental therapeutics
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PreclinicalNot FDA-approved
Dihexa
Angiotensin-IV-derived peptidomimetic
Also indexed as: N-hexanoic-Tyr-Ile-(6) aminohexanoic amide
What this evidence does not tell us
Animal cognition and synapse findings do not establish benefit in human cognitive disorders.
Terms on this page
Unfamiliar word? Open this panel for simple explanations, right here.
5 glossary terms used in this profile
Terms on this page
Unfamiliar word? Open this panel for simple explanations, right here.
5 glossary terms used in this profile
Select a word to see its meaning. You can keep more than one definition open.
Definitions explain the words—not whether a molecule works or is safe. Research education only, not medical advice.
Overview
Dihexa is a synthetic peptidomimetic developed from angiotensin-IV-related research. Its cognition-related claims remain grounded primarily in laboratory and animal work.
Mechanism of action
HGF / c-Met
Hepatocyte growth factor/c-Met pathway investigational research compound.
A biological pathway describes a proposed or observed interaction—not necessarily a demonstrated health outcome.
Decode the terminology in our glossaryScientific evidence
How strong is the evidence?
Early lab & animal research
- Limited evidence
- Early researchCurrent category
- Human research
- Human outcomes
Most support comes from cells or animals. These studies help form questions, but do not prove a treatment works in people.
For this research: Animal cognition and synapse findings do not establish benefit in human cognitive disorders.
An editorial guide—not a validated score, a percentage, a safety rating or an approval badge. Regulatory status is separate. More research does not mean fewer risks.
Cell studies
Synaptic-plasticity and growth-factor signaling hypotheses derive from laboratory research.
Animal experiments
The cited study includes rodent cognitive-behavior models.
Human observational studies
Associations, biomarker studies and anecdotes cannot establish treatment causality; no observational result is used here to infer clinical effectiveness.
Human clinical trials
Reliable, independently replicated human outcome evidence is not established by the selected sources in this edition.
Regulatory evidence
No FDA-approved finished drug for this molecule is identified in this edition. Investigational use, published research or compounding does not establish FDA approval.
Potential research applications
Synaptic plasticity and cognitive behavior in experimental models.
These describe scientific questions, not prescribing recommendations. A research grouping does not establish combination safety or clinical effectiveness.
Explore research by health goalSafety considerations
Human safety is not established. HGF/c-Met growth signaling raises unresolved safety questions; FDA has not identified human exposure data for nominated drug products.
This is not an exhaustive safety or contraindication list. An absence of reported harm is not proof of safety. Pregnancy, breastfeeding, cancer history, endocrine disease and concurrent medicines can materially change risk. Unregulated preparations add identity, contamination and sterility risks.
Read FDA’s compounding safety informationRegulatory status · United States
Not FDA-approved
No FDA-approved finished drug for this molecule is identified in this edition. Investigational use, published research or compounding does not establish FDA approval.
Regulatory status and evidence strength are different. A nomination for compounding, a clinical-trial registration or a “research use only” label is not approval. International rules vary; consult the current regulator and product label.
Selected literature & source transparency
Matched bibliographic records confirm a publication’s identity, not the validity of every claim. Selected sources are not a systematic literature review.
Continue your own source search
These open search results, not additional verified citations. Trial registration is not evidence that a treatment works.
Three questions worth bringing to your clinician
- Which human outcomes—not just biomarkers—support this claim?
- What established options address my actual health concern?
- What do my medical history and current medicines change about the risks?
Beyond the library
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