Review· 2004
Pralmorelin: GHRP 2, GPA 748, growth hormone-releasing peptide 2, KP-102 D, KP-102 LN, KP-102D, KP-102LN.
Drugs in R&D
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Human researchNot FDA-approved
GHRP-2
Synthetic growth-hormone-releasing peptide (pralmorelin)
Also indexed as: Pralmorelin
What this evidence does not tell us
Diagnostic or hormone-response research does not establish performance benefits. Non-US diagnostic use is not US FDA approval.
Terms on this page
Unfamiliar word? Open this panel for simple explanations, right here.
8 glossary terms used in this profile
Terms on this page
Unfamiliar word? Open this panel for simple explanations, right here.
8 glossary terms used in this profile
Select a word to see its meaning. You can keep more than one definition open.
Definitions explain the words—not whether a molecule works or is safe. Research education only, not medical advice.
Overview
GHRP-2, also known as pralmorelin, is a synthetic growth hormone secretagogue. Human physiology and diagnostic research do not make it an FDA-approved performance treatment.
Mechanism of action
Ghrelin / GH–IGF-1
Acts at the ghrelin receptor (GHS-R1a) to stimulate growth hormone release. Downstream endocrine responses depend on physiological context and can extend beyond GH alone.
A biological pathway describes a proposed or observed interaction—not necessarily a demonstrated health outcome.
Decode the terminology in our glossaryScientific evidence
How strong is the evidence?
Human evidence is still developing
- Limited evidence
- Early research
- Human researchCurrent category
- Human outcomes
Studies in people exist, but the findings may be small, narrow, mixed or still need confirmation. A hormone or cell marker is not necessarily a health benefit.
For this research: Diagnostic or hormone-response research does not establish performance benefits. Non-US diagnostic use is not US FDA approval.
An editorial guide—not a validated score, a percentage, a safety rating or an approval badge. Regulatory status is separate. More research does not mean fewer risks.
Cell studies
Mechanistic laboratory evidence is not separately assessed in this selected-source summary; see references and their study types.
Animal experiments
Animal evidence is not separately assessed here. Findings in animals must not be interpreted as demonstrated human benefit.
Human observational studies
Associations, biomarker studies and anecdotes cannot establish treatment causality; no observational result is used here to infer clinical effectiveness.
Human clinical trials
Human pharmacology and diagnostic research exists; the cited source is a development review.
Regulatory evidence
No FDA-approved finished drug for this molecule is identified in this edition. Investigational use, published research or compounding does not establish FDA approval.
Potential research applications
Human endocrine responses and GH-stimulation testing.
These describe scientific questions, not prescribing recommendations. A research grouping does not establish combination safety or clinical effectiveness.
Explore research by health goalSafety considerations
Endocrine and glucose effects are concerns. FDA describes serious adverse-event reports including infection and pancreatitis; causality was not established.
This is not an exhaustive safety or contraindication list. An absence of reported harm is not proof of safety. Pregnancy, breastfeeding, cancer history, endocrine disease and concurrent medicines can materially change risk. Unregulated preparations add identity, contamination and sterility risks.
Read FDA’s compounding safety informationRegulatory status · United States
Not FDA-approved
No FDA-approved finished drug for this molecule is identified in this edition. Investigational use, published research or compounding does not establish FDA approval.
Regulatory status and evidence strength are different. A nomination for compounding, a clinical-trial registration or a “research use only” label is not approval. International rules vary; consult the current regulator and product label.
Selected literature & source transparency
Matched bibliographic records confirm a publication’s identity, not the validity of every claim. Selected sources are not a systematic literature review.
Continue your own source search
These open search results, not additional verified citations. Trial registration is not evidence that a treatment works.
Three questions worth bringing to your clinician
- Which human outcomes—not just biomarkers—support this claim?
- What established options address my actual health concern?
- What do my medical history and current medicines change about the risks?
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