Unverified reference· 1999Citation not verified
Erectogenic Properties of Melanotan II in Men with Organic Erectile Dysfunction
The Journal of Urology
Bibliographic match not independently verified. Not used as support for clinical benefit.
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Limited / uncertainNot FDA-approved
Melanotan II
Nonselective melanocortin receptor agonist
Also indexed as: MT-II
What this evidence does not tell us
The reference citation could not be independently matched in this edition. FDA safety information is linked; cosmetic efficacy and long-term safety are not established.
Terms on this page
Unfamiliar word? Open this panel for simple explanations, right here.
7 glossary terms used in this profile
Terms on this page
Unfamiliar word? Open this panel for simple explanations, right here.
7 glossary terms used in this profile
Select a word to see its meaning. You can keep more than one definition open.
Definitions explain the words—not whether a molecule works or is safe. Research education only, not medical advice.
Overview
Melanotan II is a synthetic melanocortin analog associated with pigmentation and historical sexual-function research. It is not an FDA-approved tanning medication.
Mechanism of action
Melanocortin signaling
Activates multiple melanocortin receptor subtypes, affecting pigmentation and other signals. Receptor activation does not make unregulated cosmetic use safe.
A biological pathway describes a proposed or observed interaction—not necessarily a demonstrated health outcome.
Decode the terminology in our glossaryScientific evidence
How strong is the evidence?
Not enough reliable evidence
- Limited evidenceCurrent category
- Early research
- Human research
- Human outcomes
There is too little dependable or verified research here to draw a useful conclusion about benefit in people.
For this research: The reference citation could not be independently matched in this edition. FDA safety information is linked; cosmetic efficacy and long-term safety are not established.
An editorial guide—not a validated score, a percentage, a safety rating or an approval badge. Regulatory status is separate. More research does not mean fewer risks.
Cell studies
Mechanistic laboratory evidence is not separately assessed in this selected-source summary; see references and their study types.
Animal experiments
Animal evidence is not separately assessed here. Findings in animals must not be interpreted as demonstrated human benefit.
Human observational studies
Associations, biomarker studies and anecdotes cannot establish treatment causality; no observational result is used here to infer clinical effectiveness.
Human clinical trials
Reliable, independently replicated human outcome evidence is not established by the selected sources in this edition.
Regulatory evidence
No FDA-approved finished drug for this molecule is identified in this edition. Investigational use, published research or compounding does not establish FDA approval.
Potential research applications
Pigmentation and historical sexual-function research.
These describe scientific questions, not prescribing recommendations. A research grouping does not establish combination safety or clinical effectiveness.
Explore research by health goalSafety considerations
Serious case reports include priapism, neurological syndromes and melanoma; case reports do not establish causality. Changes in skin lesions warrant medical evaluation. Tanning does not ensure UV protection.
This is not an exhaustive safety or contraindication list. An absence of reported harm is not proof of safety. Pregnancy, breastfeeding, cancer history, endocrine disease and concurrent medicines can materially change risk. Unregulated preparations add identity, contamination and sterility risks.
Read FDA’s compounding safety informationRegulatory status · United States
Not FDA-approved
No FDA-approved finished drug for this molecule is identified in this edition. Investigational use, published research or compounding does not establish FDA approval.
Regulatory status and evidence strength are different. A nomination for compounding, a clinical-trial registration or a “research use only” label is not approval. International rules vary; consult the current regulator and product label.
Selected literature & source transparency
Matched bibliographic records confirm a publication’s identity, not the validity of every claim. Selected sources are not a systematic literature review.
Continue your own source search
These open search results, not additional verified citations. Trial registration is not evidence that a treatment works.
Three questions worth bringing to your clinician
- Which human outcomes—not just biomarkers—support this claim?
- What established options address my actual health concern?
- What do my medical history and current medicines change about the risks?
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