Gastroenterology · 2008 · Cell / animal study · PMID 18061177
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Preclinical evidenceLys-Pro-Val tripeptide related to alpha-MSH
KPV
KPV is the tripeptide lysine-proline-valine, corresponding to the C-terminal sequence of alpha-melanocyte-stimulating hormone. It is studied in experimental inflammatory biology.
Also indexed as: Lysine-Proline-Valine tripeptide
A clear starting point
KPV is the tripeptide lysine-proline-valine, corresponding to the C-terminal sequence of alpha-melanocyte-stimulating hormone. It is studied in experimental inflammatory biology.
Systems mapping shows biological relevance, not a treatment recommendation or a patient CPI score.
No validated chemical structure is displayed in this edition.
How it works
PepT1 / NF-κB
KPV is the tripeptide lysine-proline-valine, corresponding to the C-terminal sequence of alpha-melanocyte-stimulating hormone. It is studied in experimental inflammatory biology.
- Targets & processes
- PepT1 / NF-κB
- Systems & tissues
- See the pathway description; category links describe research relevance, not demonstrated treatment effects.
What does the evidence show?
Intestinal inflammatory signaling and experimental colitis.
What this does not establish
PepT1-mediated uptake and inflammatory changes were studied in cells and mouse colitis models, not proof of benefit for human IBD.
Citation metadata from PubMed, a service of the U.S. National Library of Medicine, NIH. A citation match is not a guarantee of study quality. Abstracts are not full-text reviews.
Safety is a separate question
FDA reports no identified human exposure data for nominated KPV drug products. Safety, interactions and effects in vulnerable populations are unknown.
Contraindications & cautions
Not an exhaustive contraindication review. FDA reports no identified human exposure data for nominated KPV drug products. Safety, interactions and effects in vulnerable populations are unknown.
Medication & supplement interactions
Interaction information is incomplete. FDA reports no identified human exposure data for nominated KPV drug products. Safety, interactions and effects in vulnerable populations are unknown.
Regulatory status · United States
Not FDA-approved. No FDA-approved finished drug for this molecule is identified in this edition. Investigational use, published research or compounding does not establish FDA approval.
Read the official sourceThis is not an exhaustive safety list. Regulatory status varies by jurisdiction and product; investigational use is not approval.
Make the science interactive
A dedicated lesson has not been published for this ingredient yet. Explore the cited profile or ask the instructor.
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Education only. Confidence labels are not formal systematic evidence grades. No patient record is used.
Education only. Confidence labels are not formal systematic evidence grades. No patient record is used.