Biochimica et biophysica acta · 2006 · Review · PMID 16716248
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Limited human evidenceHuman cathelicidin antimicrobial peptide
LL-37
LL-37 is a human cathelicidin peptide involved in innate immune biology. Its naturally occurring role does not establish the safety or efficacy of administering LL-37 as a drug.
Also indexed as: Cathelicidin antimicrobial peptide
A clear starting point
LL-37 is a human cathelicidin peptide involved in innate immune biology. Its naturally occurring role does not establish the safety or efficacy of administering LL-37 as a drug.
Systems mapping shows biological relevance, not a treatment recommendation or a patient CPI score.
No validated chemical structure is displayed in this edition.
How it works
Cathelicidin / innate immunity
LL-37 is a human cathelicidin peptide involved in innate immune biology. Its naturally occurring role does not establish the safety or efficacy of administering LL-37 as a drug.
- Targets & processes
- Cathelicidin / innate immunity
- Systems & tissues
- See the pathway description; category links describe research relevance, not demonstrated treatment effects.
What does the evidence show?
Antimicrobial defense, wound biology and immune signaling.
What this does not establish
The linked review is background biology, not proof of systemic infection treatment. Limited clinical wound research cannot validate unrelated systemic uses.
Citation metadata from PubMed, a service of the U.S. National Library of Medicine, NIH. A citation match is not a guarantee of study quality. Abstracts are not full-text reviews.
Safety is a separate question
FDA cites inadequate human safety information and nonclinical reproductive and protumorigenic concerns in some tissues. Inflammatory effects are context-dependent.
Contraindications & cautions
Not an exhaustive contraindication review. FDA cites inadequate human safety information and nonclinical reproductive and protumorigenic concerns in some tissues. Inflammatory effects are context-dependent.
Medication & supplement interactions
Interaction information is incomplete. FDA cites inadequate human safety information and nonclinical reproductive and protumorigenic concerns in some tissues. Inflammatory effects are context-dependent.
Regulatory status · United States
Not FDA-approved. No FDA-approved finished drug for this molecule is identified in this edition. Investigational use, published research or compounding does not establish FDA approval.
Read the official sourceThis is not an exhaustive safety list. Regulatory status varies by jurisdiction and product; investigational use is not approval.
Make the science interactive
A dedicated lesson has not been published for this ingredient yet. Explore the cited profile or ask the instructor.
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Basic level · Published sources only · AI evidence check
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IW Interactive Learning Engine · Adapted from stable OpenMAIC v1.2.1. Open-source license
Education only. Confidence labels are not formal systematic evidence grades. No patient record is used.
Education only. Confidence labels are not formal systematic evidence grades. No patient record is used.