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Limited human evidenceBotanical / withanolide-containing ingredient

Ashwagandha

Ashwagandha is studied for stress and sleep outcomes. Small trials and different extracts make claims uncertain; natural origin does not rule out thyroid effects or liver injury.

Also indexed as: Withania somnifera · Withanolides

A clear starting point

Ashwagandha is studied for stress and sleep outcomes. Small trials and different extracts make claims uncertain; natural origin does not rule out thyroid effects or liver injury.

Systems mapping shows biological relevance, not a treatment recommendation or a patient CPI score.

No validated chemical structure is displayed in this edition.

How it works

Stress- and sleep-outcome research

Ashwagandha is studied for stress and sleep outcomes. Small trials and different extracts make claims uncertain; natural origin does not rule out thyroid effects or liver injury.

Targets & processes
Withanolide-containing preparations; no single validated clinical target explains every claimed effect.
Systems & tissues
Stress/sleep research; thyroid and liver safety are relevant.

What does the evidence show?

Some preparations show signals for short-term stress or insomnia-related outcomes. Evidence for broad cognition, athletic or disease-treatment claims is not established by this profile.

What this does not establish

Extracts, study populations and outcomes differ. Short follow-up cannot establish long-term benefit or safety.

NCCIH: Ashwagandha — Usefulness and Safety

Official educational / regulatory source · Official educational source

Some preparations show signals for short-term stress or insomnia-related outcomes. Evidence for broad cognition, athletic or disease-treatment claims is not established by this profile.

Limitations: Extracts, study populations and outcomes differ. Short follow-up cannot establish long-term benefit or safety.

Citation metadata from PubMed, a service of the U.S. National Library of Medicine, NIH. A citation match is not a guarantee of study quality. Abstracts are not full-text reviews.

Safety is a separate question

Drowsiness, stomach upset, diarrhea and vomiting can occur. Rare liver injury has been reported; thyroid-related effects require caution.

Contraindications & cautions

Avoid during pregnancy; breastfeeding, thyroid/autoimmune disorders, planned surgery and hormone-sensitive prostate cancer require professional review.

Medication & supplement interactions

May interact with sedatives, anticonvulsants, immunosuppressants, thyroid medicines and medicines for blood pressure or diabetes.

Regulatory status · United States

United States: dietary-supplement status is product-specific, not FDA approval of disease treatment. Food, supplement and drug formulations must not be assumed interchangeable.

Read the official source

This is not an exhaustive safety list. Regulatory status varies by jurisdiction and product; investigational use is not approval.

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A dedicated lesson has not been published for this ingredient yet. Explore the cited profile or ask the instructor.

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Education, not a prescription. Research summaries are not medical advice, dosing instructions, or an offer to sell. Mechanistic findings do not establish clinical effectiveness. US regulatory status is product- and indication-specific and may change. Discuss health decisions with a licensed clinician.