Proceedings of the National Academy of Sciences of the United States of America · 2001 · Cell / animal study · PMID 11371646
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Preclinical evidenceMitochondrial-derived peptide
Humanin
Humanin is a mitochondrial-derived peptide first characterized in laboratory neuroprotection research. Studies of an endogenous peptide are different from evidence supporting administration of a manufactured product.
Also indexed as: HN · MOTS variants family
A clear starting point
Humanin is a mitochondrial-derived peptide first characterized in laboratory neuroprotection research. Studies of an endogenous peptide are different from evidence supporting administration of a manufactured product.
Systems mapping shows biological relevance, not a treatment recommendation or a patient CPI score.
No validated chemical structure is displayed in this edition.
How it works
Mitochondrial stress signaling
Humanin is a mitochondrial-derived peptide first characterized in laboratory neuroprotection research. Studies of an endogenous peptide are different from evidence supporting administration of a manufactured product.
- Targets & processes
- Mitochondrial stress signaling
- Systems & tissues
- See the pathway description; category links describe research relevance, not demonstrated treatment effects.
What does the evidence show?
Cell survival and neuroprotection hypotheses.
What this does not establish
The linked discovery study is laboratory neuroprotection research, not a dementia treatment trial.
Citation metadata from PubMed, a service of the U.S. National Library of Medicine, NIH. A citation match is not a guarantee of study quality. Abstracts are not full-text reviews.
Safety is a separate question
Human administration, long-term effects and interactions are insufficiently characterized. Endogenous occurrence does not prove a manufactured preparation is safe.
Contraindications & cautions
Not an exhaustive contraindication review. Human administration, long-term effects and interactions are insufficiently characterized. Endogenous occurrence does not prove a manufactured preparation is safe.
Medication & supplement interactions
Interaction information is incomplete. Human administration, long-term effects and interactions are insufficiently characterized. Endogenous occurrence does not prove a manufactured preparation is safe.
Regulatory status · United States
Not FDA-approved. No FDA-approved finished drug for this molecule is identified in this edition. Investigational use, published research or compounding does not establish FDA approval.
This is not an exhaustive safety list. Regulatory status varies by jurisdiction and product; investigational use is not approval.
Make the science interactive
A dedicated lesson has not been published for this ingredient yet. Explore the cited profile or ask the instructor.
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Basic level · Published sources only · AI evidence check
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IW Interactive Learning Engine · Adapted from stable OpenMAIC v1.2.1. Open-source license
Education only. Confidence labels are not formal systematic evidence grades. No patient record is used.
Education only. Confidence labels are not formal systematic evidence grades. No patient record is used.