Journal of Clinical Endocrinology & Metabolism · 2011 · Human physiology study · PMID 21632807
Limitations: Hormone-response endpoint, not proof of general fertility efficacy.
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Limited human evidenceKisspeptin decapeptide fragment
Kisspeptin-10
Kisspeptin-10 is a ten-amino-acid fragment of the kisspeptin peptide family. The family has an important role in reproductive signaling, but findings from different kisspeptin lengths are not interchangeable.
Also indexed as: Metastin fragment 45-54
A clear starting point
Kisspeptin-10 is a ten-amino-acid fragment of the kisspeptin peptide family. The family has an important role in reproductive signaling, but findings from different kisspeptin lengths are not interchangeable.
Systems mapping shows biological relevance, not a treatment recommendation or a patient CPI score.
No validated chemical structure is displayed in this edition.
How it works
KISS1R / GnRH
Kisspeptin-10 is a ten-amino-acid fragment of the kisspeptin peptide family. The family has an important role in reproductive signaling, but findings from different kisspeptin lengths are not interchangeable.
- Targets & processes
- KISS1R / GnRH
- Systems & tissues
- See the pathway description; category links describe research relevance, not demonstrated treatment effects.
What does the evidence show?
Reproductive hormone signaling and GnRH/LH responses.
What this does not establish
Kisspeptin-10 physiology studies must be distinguished from kisspeptin-54 IVF trials. Evidence for the longer form does not automatically apply to this fragment.
The Journal of clinical investigation · 2014 · Clinical trial · PMID 25036713
Limitations: Related molecule only: kisspeptin-54, not kisspeptin-10.
Citation metadata from PubMed, a service of the U.S. National Library of Medicine, NIH. A citation match is not a guarantee of study quality. Abstracts are not full-text reviews.
Safety is a separate question
Effects vary by sex and endocrine state. FDA highlights limited safety information and immunogenicity concerns. Reproductive-axis manipulation requires specialist assessment.
Contraindications & cautions
Not an exhaustive contraindication review. Effects vary by sex and endocrine state. FDA highlights limited safety information and immunogenicity concerns. Reproductive-axis manipulation requires specialist assessment.
Medication & supplement interactions
Interaction information is incomplete. Effects vary by sex and endocrine state. FDA highlights limited safety information and immunogenicity concerns. Reproductive-axis manipulation requires specialist assessment.
Regulatory status · United States
Not FDA-approved. No FDA-approved finished drug for this molecule is identified in this edition. Investigational use, published research or compounding does not establish FDA approval.
Read the official sourceThis is not an exhaustive safety list. Regulatory status varies by jurisdiction and product; investigational use is not approval.
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A dedicated lesson has not been published for this ingredient yet. Explore the cited profile or ask the instructor.
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Basic level · Published sources only · AI evidence check
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All medications and therapies discussed are for educational purposes only. Prescriptions are determined independently by the licensed clinician following a medical evaluation. There is no guarantee that any medication or peptide will be prescribed.
IW Interactive Learning Engine · Adapted from stable OpenMAIC v1.2.1. Open-source license
Education only. Confidence labels are not formal systematic evidence grades. No patient record is used.
Education only. Confidence labels are not formal systematic evidence grades. No patient record is used.