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Urolithin A is a metabolite some gut microbes produce from dietary precursors. Supplement trials investigate mitochondrial and muscle outcomes; it is not an established anti-aging treatment.
Also indexed as: UA
Cells recycle damaged parts, including mitochondria. Urolithin A is studied in relation to that recycling process. A laboratory effect does not tell us that people live longer.
Systems mapping shows biological relevance, not a treatment recommendation or a patient CPI score.
No validated chemical structure is displayed in this edition.
Mitophagy / mitochondrial quality control
Cells recycle damaged parts, including mitochondria. Urolithin A is studied in relation to that recycling process. A laboratory effect does not tell us that people live longer.
Small trials show some muscle-endurance or biomarker signals; primary outcomes in the cited trial were not significantly improved.
Small samples, limited follow-up and selected populations leave uncertainty about general function, long-term safety and clinical aging outcomes.
JAMA network open · 2022 · Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't · PMID 35050355
Verified sample: 66 · Adults aged 65–90; all White; predominantly women
Primary 6-minute walk and maximal ATP outcomes were not significantly different. Some secondary muscle-endurance and biomarker outcomes improved.
Limitations: Small, short study; secondary outcomes do not prove general anti-aging effects.
Citation metadata from PubMed, a service of the U.S. National Library of Medicine, NIH. A citation match is not a guarantee of study quality. Abstracts are not full-text reviews.
Short studies reported tolerability in selected adults; this cannot establish long-term safety or safety in vulnerable groups.
Pregnancy, breastfeeding and significant illness lack adequate evidence in this profile.
Medication interaction studies are limited. Absence of a reported interaction is not proof of compatibility.
United States: sold as a dietary supplement, not an FDA-approved drug for disease treatment. Ingredient research does not validate every marketed product.
This is not an exhaustive safety list. Regulatory status varies by jurisdiction and product; investigational use is not approval.
A dedicated lesson has not been published for this ingredient yet. Explore the cited profile or ask the instructor.
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Education, not a prescription. Research summaries are not medical advice, dosing instructions, or an offer to sell. Mechanistic findings do not establish clinical effectiveness. US regulatory status is product- and indication-specific and may change. Discuss health decisions with a licensed clinician.
