Explore the library
Moderate human evidenceEssential mineral

Magnesium

Magnesium is an essential mineral involved in energy use, muscle activity and nerve signaling. Different salts deliver magnesium; their labels are not evidence that one treats a condition better.

Also indexed as: Magnesium glycinate · Magnesium citrate · Mg

A clear starting point

Magnesium helps many enzymes do their jobs, including those that use energy. It also participates in nerve and muscle function. Correcting a shortage is different from adding extra magnesium when intake is already adequate.

Systems mapping shows biological relevance, not a treatment recommendation or a patient CPI score.

No validated chemical structure is displayed in this edition.

How it works

Mg–ATP reactions / ion transport

Magnesium helps many enzymes do their jobs, including those that use energy. It also participates in nerve and muscle function. Correcting a shortage is different from adding extra magnesium when intake is already adequate.

Targets & processes
Magnesium-dependent enzymes and membrane ion transport
Systems & tissues
Muscle, nerves, bone, intestine and kidneys.

What does the evidence show?

Deficiency correction is established. Evidence for blood-pressure or sleep improvements depends on population and study design; no general sleep-treatment benefit is established here.

What this does not establish

This mineral profile does not establish superiority of glycinate versus citrate. A normal serum value does not fully characterize stores, and a pathway role is not an efficacy claim.

Citation metadata from PubMed, a service of the U.S. National Library of Medicine, NIH. A citation match is not a guarantee of study quality. Abstracts are not full-text reviews.

Safety is a separate question

Supplemental magnesium can cause diarrhea, nausea and cramping. Toxic accumulation can occur when kidney function is impaired.

Contraindications & cautions

Significant kidney impairment increases toxicity risk. Severe weakness, low blood pressure or rhythm disturbances require clinical assessment.

Medication & supplement interactions

Can reduce absorption of tetracycline/quinolone antibiotics and oral bisphosphonates. Diuretics and proton-pump inhibitors can affect magnesium status. Ask a pharmacist about medicine-specific timing.

Regulatory status · United States

United States: sold as a dietary supplement, not an FDA-approved drug for disease treatment. Ingredient research does not validate every marketed product.

This is not an exhaustive safety list. Regulatory status varies by jurisdiction and product; investigational use is not approval.

Make the science interactive

IW Interactive Learning Engine · 5 minutes

Magnesium: one mineral, many roles

Explore the pathway & test your understanding

Your scientific classroom

Ask the IW Science Instructor

Basic level · Published sources only · AI evidence check

Ask about general science. Do not enter names, personal health details or medication lists. This is not a clinical consultation. Discussion stays in this browser’s private learning session for up to 90 days.

Answers checked before they appear
All medications and therapies discussed are for educational purposes only. Prescriptions are determined independently by the licensed clinician following a medical evaluation. There is no guarantee that any medication or peptide will be prescribed.
IW Interactive Learning Engine · Adapted from stable OpenMAIC v1.2.1. Open-source license
Education only. Confidence labels are not formal systematic evidence grades. No patient record is used.

Education, not a prescription. Research summaries are not medical advice, dosing instructions, or an offer to sell. Mechanistic findings do not establish clinical effectiveness. US regulatory status is product- and indication-specific and may change. Discuss health decisions with a licensed clinician.